The CEO should initiate an alert to department managers to speak privately with affected staff.
This is because the trade secret is confidential and should not be disclosed to the public.
Additionally, the CEO should verify legal notification requirements of PII and SPII in the legal and human resource departments to ensure compliance with data protection laws.

A System Isolation stops malware from spreading, but it doesn't restore the system. This is an initial containment step, not a business continuity solution. Reimaging, because is the most reliable way to restore a compromised system to a clean state.

System hardening is the process of securing a system by reducing its attack surface, applying patches and updates, configuring security settings, and implementing security controls. System hardening can help prevent or mitigate vulnerability events that may affect operating systems.
Host-based IPS, firewalls, and two-factor authentication are examples of security controls that can be applied to harden a system.

Port 1433 is commonly used by Microsoft SQL Server, which is a database management system.
A spike in traffic on this port between two IP addresses on opposite sides of a WAN connection could indicate a database replication process, which is a way of copying and distributing data from one database server to another. This could be a legitimate activity performed by an administrator, but it should be communicated to the security operations center (SOC) to avoid confusion and false alarms.